The structural involvement of the cingulate cortex in premanifest and early Huntington's disease
Identifieur interne : 001308 ( Main/Exploration ); précédent : 001307; suivant : 001309The structural involvement of the cingulate cortex in premanifest and early Huntington's disease
Auteurs : Nicola Z. Hobbs [Royaume-Uni] ; Amy V. Pedrick [Royaume-Uni] ; Miranda J. Say [Royaume-Uni] ; Chris Frost [Royaume-Uni] ; Rachelle Dar Santos [Canada] ; Allison Coleman [Canada] ; Aaron Sturrock [Canada] ; David Craufurd [Royaume-Uni] ; Julie C. Stout [Australie] ; Blair R. Leavitt [Canada] ; Josephine Barnes [Royaume-Uni] ; Sarah J. Tabrizi [Royaume-Uni] ; Rachael I. Scahill [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-08-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Cingulate cortex, Cognition Disorders (diagnosis), Cognition Disorders (etiology), Female, Gyrus Cinguli (pathology), Gyrus Cinguli (physiopathology), Humans, Huntington Disease (complications), Huntington Disease (pathology), Huntington disease, Huntington's disease, Imaging, Three-Dimensional (methods), Magnetic Resonance Imaging, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Nuclear magnetic resonance imaging, Psychiatric Status Rating Scales, Statistics as Topic, Young Adult, cingulate cortex, magnetic resonance imaging.
- MESH :
- complications : Huntington Disease.
- diagnosis : Cognition Disorders.
- etiology : Cognition Disorders.
- methods : Imaging, Three-Dimensional.
- pathology : Gyrus Cinguli, Huntington Disease.
- physiopathology : Gyrus Cinguli.
- Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Statistics as Topic, Young Adult.
Abstract
The impact of Huntington's disease neuropathology on the structure of the cingulate is uncertain, with evidence of both cortical enlargement and atrophy in this structure in early clinical disease. We sought to determine differences in cingulate volume between premanifest Huntington's disease and early Huntington's disease groups compared with controls using detailed manual measurements. Thirty controls, 30 subjects with premanifest Huntington's disease, and 30 subjects with early Huntington's disease were selected from the Vancouver site of the TRACK‐HD study. Subjects underwent 3 Tesla magnetic resonance imaging and motor, cognitive, and neuropsychiatric assessment. The cingulate was manually delineated and subdivided into rostral, caudal, and posterior segments. Group differences in volume and associations with performance on 4 tasks thought to utilize cingulate function were examined, with adjustment for appropriate covariates. Cingulate volumes were, on average, 1.7 mL smaller in early Huntington's disease (P = .001) and 0.9 mL smaller in premanifest Huntington's disease (P = .1) compared with controls. Smaller volumes in subsections of the cingulate were associated with impaired recognition of negative emotions (P = .04), heightened depression (P = .009), and worse visual working memory performance (P = .01). There was no evidence of associations between volume and ability on a performance‐monitoring task. This study disputes previous findings of enlargement of the cingulate cortex in Huntington's disease and instead suggests that the cingulate undergoes structural degeneration during early Huntington's disease with directionally consistent, nonsignificant differences seen in premanifest Huntington's disease. Cingulate atrophy may contribute to deficits in mood, emotional processing, and visual working memory in Huntington's disease. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23747
Affiliations:
- Australie, Canada, Royaume-Uni
- Angleterre, Grand Londres, Grand Manchester
- Londres, Manchester
- Université de Manchester
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Le document en format XML
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Hobbs</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pedrick, Amy V" sort="Pedrick, Amy V" uniqKey="Pedrick A" first="Amy V." last="Pedrick">Amy V. 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Leavitt</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Barnes, Josephine" sort="Barnes, Josephine" uniqKey="Barnes J" first="Josephine" last="Barnes">Josephine Barnes</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Centre, UCL Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Scahill, Rachael I" sort="Scahill, Rachael I" uniqKey="Scahill R" first="Rachael I." last="Scahill">Rachael I. Scahill</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-08-01">2011-08-01</date><biblScope unit="vol">26</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1684">1684</biblScope><biblScope unit="page" to="1690">1690</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AF3B865F30DD0E54535373EB390C50FABB171433</idno><idno type="DOI">10.1002/mds.23747</idno><idno type="ArticleID">MDS23747</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cingulate cortex</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Female</term><term>Gyrus Cinguli (pathology)</term><term>Gyrus Cinguli (physiopathology)</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (pathology)</term><term>Huntington disease</term><term>Huntington's disease</term><term>Imaging, Three-Dimensional (methods)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Nuclear magnetic resonance imaging</term><term>Psychiatric Status Rating Scales</term><term>Statistics as Topic</term><term>Young Adult</term><term>cingulate cortex</term><term>magnetic resonance imaging</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Imaging, Three-Dimensional</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gyrus Cinguli</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Gyrus Cinguli</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychiatric Status Rating Scales</term><term>Statistics as Topic</term><term>Young Adult</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chorée de Huntington</term><term>Cortex cingulaire</term><term>Imagerie RMN</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The impact of Huntington's disease neuropathology on the structure of the cingulate is uncertain, with evidence of both cortical enlargement and atrophy in this structure in early clinical disease. We sought to determine differences in cingulate volume between premanifest Huntington's disease and early Huntington's disease groups compared with controls using detailed manual measurements. Thirty controls, 30 subjects with premanifest Huntington's disease, and 30 subjects with early Huntington's disease were selected from the Vancouver site of the TRACK‐HD study. Subjects underwent 3 Tesla magnetic resonance imaging and motor, cognitive, and neuropsychiatric assessment. The cingulate was manually delineated and subdivided into rostral, caudal, and posterior segments. Group differences in volume and associations with performance on 4 tasks thought to utilize cingulate function were examined, with adjustment for appropriate covariates. Cingulate volumes were, on average, 1.7 mL smaller in early Huntington's disease (P = .001) and 0.9 mL smaller in premanifest Huntington's disease (P = .1) compared with controls. Smaller volumes in subsections of the cingulate were associated with impaired recognition of negative emotions (P = .04), heightened depression (P = .009), and worse visual working memory performance (P = .01). There was no evidence of associations between volume and ability on a performance‐monitoring task. This study disputes previous findings of enlargement of the cingulate cortex in Huntington's disease and instead suggests that the cingulate undergoes structural degeneration during early Huntington's disease with directionally consistent, nonsignificant differences seen in premanifest Huntington's disease. Cingulate atrophy may contribute to deficits in mood, emotional processing, and visual working memory in Huntington's disease. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Grand Manchester</li></region><settlement><li>Londres</li><li>Manchester</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hobbs, Nicola Z" sort="Hobbs, Nicola Z" uniqKey="Hobbs N" first="Nicola Z." last="Hobbs">Nicola Z. Hobbs</name></region><name sortKey="Barnes, Josephine" sort="Barnes, Josephine" uniqKey="Barnes J" first="Josephine" last="Barnes">Josephine Barnes</name><name sortKey="Craufurd, David" sort="Craufurd, David" uniqKey="Craufurd D" first="David" last="Craufurd">David Craufurd</name><name sortKey="Frost, Chris" sort="Frost, Chris" uniqKey="Frost C" first="Chris" last="Frost">Chris Frost</name><name sortKey="Pedrick, Amy V" sort="Pedrick, Amy V" uniqKey="Pedrick A" first="Amy V." last="Pedrick">Amy V. Pedrick</name><name sortKey="Say, Miranda J" sort="Say, Miranda J" uniqKey="Say M" first="Miranda J." last="Say">Miranda J. Say</name><name sortKey="Scahill, Rachael I" sort="Scahill, Rachael I" uniqKey="Scahill R" first="Rachael I." last="Scahill">Rachael I. Scahill</name><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name></country><country name="Canada"><noRegion><name sortKey="Dar Santos, Rachelle" sort="Dar Santos, Rachelle" uniqKey="Dar Santos R" first="Rachelle" last="Dar Santos">Rachelle Dar Santos</name></noRegion><name sortKey="Coleman, Allison" sort="Coleman, Allison" uniqKey="Coleman A" first="Allison" last="Coleman">Allison Coleman</name><name sortKey="Leavitt, Blair R" sort="Leavitt, Blair R" uniqKey="Leavitt B" first="Blair R." last="Leavitt">Blair R. Leavitt</name><name sortKey="Sturrock, Aaron" sort="Sturrock, Aaron" uniqKey="Sturrock A" first="Aaron" last="Sturrock">Aaron Sturrock</name></country><country name="Australie"><noRegion><name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C." last="Stout">Julie C. Stout</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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